I think for now I'm going to go with Crashplan business, mainly because it's 75% off. I'll push this off for a year and save a few bucks.
My user folder and my data drive are just over 500GB so not a huge backup, but still, CP is currently dead and waiting even a week to backup to BB hurts a little.
I do have O365 so I've got 1TB there. I actually store some Windows user folder (docs/music/images/videos) directly into OneDrive. I just don't want to use it as a "backup" in the fuller sense of the word. It's not exactly protected from crypto and would be a huge pain to recover from.