as a guy who has issues with hormone levels (and I'm only 23) I can say it affect just about everything. Engery levels, dizziness, brain fog, attitude, blood sugar, weight gain, blood pressure, heart rate and palpitations. Luckily for guys it's not to bad with replacement therapy but it's dang expensive about $1,700 for a 3 month supply. They do think a lot of this stuff is caused by all the food being genetically modified though, which makes you think.