If you're an introvert expect to be exhausted at the end of the day, like unusually so. When I went to SpiceWorld '14 it was my first IT conference, and by the time things wrapped up at the end of the day (usually 3-4) I was wiped out. I just went back to my hotel and crashed.
Don't bring a heavy laptop if you can avoid it. Even if you have to borrow something it is worth reducing your carrying around weight.
Contrary to advice others might give, I prefer not to drink much in the way of alcohol when I'm out of town. There are too many opportunities to do something you really regret when you don't have your normal routines and environments. You might even get locked in a parking garage (funny story that happened to @scottalanmiller if you're curious).
Don't count on getting anything done/read/fixed while you're there. It won't happen, or if you try it, it won't go well (generally speaking). Emergencies are another matter, but don't count on the above happening, or promise anyone that they will.