Building Python GUI Applications Comparing Frameworks
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Python is one of the most popular languages for writing cross-platform GUI applications (the kind that you run on your desktop) and there are two major competing frameworks, Wx and QT, for providing this functionality. QT is famous for being the foundation of the KDE project, as well.
See how Python GUI Frameworks Compare so you are ready for your next desktop app project.
Both are cross platform giving you access to Windows, Mac and Linux deployment platforms.
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for direct experience (5 year development of small/medium apps in python) I can say that the qt approach is far superior.
I've used briefly gtk2, wxwidgets and I've settled with qt.The signal/slot stuff per se is a winner!