So the exclusions I've had to add to get everything "functional" are listed below.
File System Shield
C:\Program Files (x86)\Meraki\m_agent_upgrade.exe
C:\Program Files (x86)\Meraki\meraki-ca-bundle.crt
C:\Program Files (x86)\Meraki\ndisscan.exe
C:\Program Files (x86)\Meraki\README-winvnc.txt
C:\Program Files (x86)\Meraki\screenshot-cmd.exe
C:\Program Files (x86)\Meraki\windows-wlan.exe
C:\Program Files (x86)\Meraki\winvnc.exe
Mail Shield
Inbound Mail - Un-check 'Scan inbound mail (POP3, IMAP4)' (UltraVNC)
Web Shield Process Exclusions
The same processes as in File System Shield